In 2006, art collector and entrepreneur Steve Wilson opened the first 21c Museum Hotel in Louisville, Kentucky, a unique hybrid of a boutique hotel and gallery space where visitors can experience world-class contemporary art without the cost of museum admission. "In Frame: The Man Behind The Museum Hotels" follows Wilson for more than a year as he builds his latest Museum Hotel in Durham, North Carolina, navigating a maze of art fairs and construction sites to bring his artistic vision to life.