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The polio crusade was a time when Americans banded together to conquer a terrible disease.

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Walt Whitman offered up his poetry as a perfect reflection of the America he saw.

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The international race to develop biological weapons during the 20th century.

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Alexander Hamilton was a gifted statesman brought down by fatal flaws.

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Great Fever documents the efforts of Major Walter Reed's investigation into yellow fever.

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When the first human egg was fertilized in a lab in 1944, the news spread like wildfire.

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In 1848 James Marshall found gold and unleashed a massive migration from around the world.

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In 1978 over 900 people died in the largest mass murder-suicide in history.

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Annie Oakley won fame and fortune as the little lady from Ohio who never missed a shot.

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Airs Tuesday, May 7, 2013 at 8:00 p.m. ET/PT. Check your local listings.

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Theirs was a rivalry that would draw American and Germany inching closer to war.

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In May of 1942, thousands of American soldiers began the building of the Alaska Highway.